As you say mate a bit of a break before the next game so rest a few but shouldn't be to much of a worry if we don't, Jose always goes strong in cups and he will be especially wary after the Bristol City nightmare the other week.
Romero in goal, personally I would like to see Tuanzebe start, Smalling to get his fitness up, Shaw, maybe Lindelof, the more starts the better for him.
I would rest Matic, play maybe Pogba/McTominey in the two.
Can't see to many being rested up top, I would give Martial another go up front, Rashford on the left, Lingard 10 and then either Mata/Mhiki on the right.